If we only did what was comfortable, we would never make any progressions. Challenge is part of growth but if you are your first obstacle, then you will never even try. No matter how ludicrous, never say no to yourself once you remove that impediment then you can start working out what you need to do, if you have the experience or skills, then getting down to complete the application or if you don't have the skills then what can you do to either acquire them or demonstrate you can pick that skill up quickly in the new role. Finally, make sure you read the application and provide them with the information they need to make it easy to appoint you or invite you for interview. The number of applications I see without any reference to the role they are applying for is really disappointing, so make sure what your application says is appropriate.